diff --git a/lang/python/python-cryptography/Makefile b/lang/python/python-cryptography/Makefile
index 2c5037d8ab..360c4f1f80 100644
--- a/lang/python/python-cryptography/Makefile
+++ b/lang/python/python-cryptography/Makefile
@@ -8,18 +8,18 @@
 include $(TOPDIR)/rules.mk
 
 PKG_NAME:=python-cryptography
-PKG_VERSION:=41.0.7
+PKG_VERSION:=46.0.6
 PKG_RELEASE:=1
 
 PYPI_NAME:=cryptography
-PKG_HASH:=13f93ce9bea8016c253b34afc6bd6a75993e5c40672ed5405a9c832f0d4a00bc
+PKG_HASH:=27550628a518c5c6c903d84f637fbecf287f6cb9ced3804838a1295dc1fd0759
 
 PKG_LICENSE:=Apache-2.0 BSD-3-Clause
 PKG_LICENSE_FILES:=LICENSE.APACHE LICENSE.BSD
 PKG_MAINTAINER:=Jeffery To <jeffery.to@gmail.com>
 PKG_CPE_ID:=cpe:/a:cryptography.io:cryptography
 
-PKG_BUILD_DEPENDS:=libffi/host python-cffi/host python-setuptools-rust/host
+PKG_BUILD_DEPENDS:=libffi/host python-cffi/host python-maturin/host python-setuptools/host
 
 include ../pypi.mk
 include $(INCLUDE_DIR)/package.mk
diff --git a/lang/python/python-cryptography/patches/001-Update-ouroboros.patch b/lang/python/python-cryptography/patches/001-Update-ouroboros.patch
deleted file mode 100644
index 93abe3a4f1..0000000000
--- a/lang/python/python-cryptography/patches/001-Update-ouroboros.patch
+++ /dev/null
@@ -1,13 +0,0 @@
-Fixes https://rustsec.org/advisories/RUSTSEC-2023-0042.html
-
---- a/src/rust/Cargo.toml
-+++ b/src/rust/Cargo.toml
-@@ -15,7 +15,7 @@ cryptography-cffi = { path = "cryptograp
- cryptography-x509 = { path = "cryptography-x509" }
- cryptography-openssl = { path = "cryptography-openssl" }
- pem = "1.1"
--ouroboros = "0.15"
-+ouroboros = "0.18"
- openssl = "0.10.54"
- openssl-sys = "0.9.88"
- foreign-types-shared = "0.1"